Bordetella bronchiseptica

Bordetella bronchiseptica

MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES

SECTION I - INFECTIOUS AGENT

NAME: Bordetella bronchiseptica

SYNONYM OR CROSS REFERENCE: Bacillus bronchiseptica, Brucella bronchiseptica, Hemophilus bronchiseptica, Kennel cough (in dogs), atrophic rhinitis (in swine)

CHARACTERISTICS: Gram-negative coccobacilli, aerobic, motile, grows sparsely on nutrient agar

SECTION II - HEALTH HAZARD

PATHOGENICITY: Rarely found in humans, however can cause pertussis-like symptoms in immunocompetent hosts; in immunocompromised hosts, illness can range in severity from mild respiratory symptoms to pneumonia; carrier state may exist

EPIDEMIOLOGY: Worldwide

HOST RANGE: Humans, rodents, swine, dogs, cats and non-human primates

INFECTIOUS DOSE: Unknown

MODE OF TRANSMISSION: Direct contact with infectious droplets and aerosols

INCUBATION PERIOD: Unknown

COMMUNICABILITY: Communicable from person to person through coughing and the generation of infectious droplets

SECTION III - DISSEMINATION

RESERVOIR: Infected persons, rodents, swine, dogs and lower primates

ZOONOSIS: Yes, can be transmitted from infected animals to humans by infected aerosols, probably droplets

VECTORS: None

SECTION IV - VIABILITY

DRUG SUSCEPTIBILITY: Susceptible in vitro to gentamicin, tobramycin, amikacin, some penicillins, some cephalosporins, chloramphenicol and tetracycline

DRUG RESISTANCE: Resistant to erythromycin

SUSCEPTIBILITY TO DISINFECTANTS: Sensitive to many disinfectants - 1% sodium hypochlorite, 70% ethanol, glutaraldehyde, formaldehyde, iodines, phenolics

PHYSICAL INACTIVATION: Susceptible to moist heat (121°C for at least 1 hour) and dry heat 160-170°C for at least 1 hour

SURVIVAL OUTSIDE HOST: Does not survive well outside of host; sensitive to drying and cold temperatures; has been shown to survive ~24 weeks in phosphate-buffered saline and lakewater

SECTION V - MEDICAL

SURVEILLANCE: Monitor for symptoms

FIRST AID/TREATMENT: Antibiotic treatment may be considered

IMMUNIZATION: None available for humans

PROPHYLAXIS: None

SECTION VI - LABORATORY HAZARDS

LABORATORY-ACQUIRED INFECTIONS: Low risk of laboratory-acquired infection

SOURCES/SPECIMENS: Respiratory specimens

PRIMARY HAZARDS: Direct contact of mucous membranes with infectious aerosols and droplets

SPECIAL HAZARDS: B. bronchiseptica is a frequent cause of bronchopneumonia in animals; infected animals may generate infectious aerosols

SECTION VII - RECOMMENDED PRECAUTIONS

CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment equipment and facilities for work with known or potentially infectious specimens and cultures; work likely to generate aerosols should be carried out in a biosafety cabinet

PROTECTIVE CLOTHING: Laboratory coat; gloves when direct contact with infectious materials is unavoidable; gloves and gown (tight wrists and ties in back) should be worn for procedures conducted in the biosafety cabinet

OTHER PRECAUTIONS: Caution should be exercised when working with infected animals

SECTION VIII - HANDLING INFORMATION

SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill with paper towels and apply 1% sodium hypochlorite, starting at perimeter and working towards the centre; allow sufficient contact time (30 min) before clean up

DISPOSAL: Decontaminate before disposal; steam sterilization, chemical disinfection, incineration

STORAGE: In sealed containers that are labelled appropriately

SECTION IX - MISCELLANEOUS INFORMATION

Date prepared: November 1999

Prepared by: Office of Laboratory Security, PHAC

Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date.

Copyright © Health Canada, 2001

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