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Defined by OSHA as a chemical which falls in any of these
three categories:
1. A chemical that has a median lethal dose (LD50) of more than 50 milligrams per kilogram but not more than
500 milligrams per kilogram of body weight when administered orally to albino rats weighing between 200 and
300 grams each.
2. A chemical that has a median lethal dose (LD50) of more than 200 milligrams per kilogram but not more than
1,000 milligrams per kilogram of body weight when administered by continuous contact for 24 hours (or less if
death occurs within 24 hours) with the bare skin of albino rabbits weighing between two and three kilograms each.
3. A chemical that has a median lethal concentration (LC50) in air of more than 200 parts per million but not
more than 2,000 parts per million by volume of gas or vapor, or more than two milligrams per liter but not more
than 20 milligrams per liter of mist, fume, or dust, when administered by continuous inhalation for one hour
(or less if death occurs within one hour) to albino rats weighing between 200 and 300 grams each.
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